Balashova T S, Rud'ko I A, Ermolenko V M, Tsalenchuk Ia P, Kubatiev A A
Ter Arkh. 1992;64(6):66-9.
Ten patients with chronic renal failure (CRF) treated by hemodialysis (HD) were examined. All the patients demonstrated remarkable anemia. The red blood cell count was (2.7 +/- 0.2) x 10(12)/I the concentration of hemoglobin 79.5 +/- 5.6 g/l, on the average, hematocrit 23.2 +/- 1.8%. The content of malonic dialdehyde in the patients' red blood cells was far greater than in controls, amounting to 132% (per 1 ml of hemolysate), 134% (per 1 mg of protein) (p < 0.05). Catalase and glutathione peroxidase activity in the patients' red blood cells did not differ from that in controls. Superoxide dismutase activity reduced by 43% as compared to that in donors (p < 0.001). The authors review possible mechanisms of lipid peroxidation (LPO) and a decrease of antioxidant defense in red blood cells of CRF patients on hemodialysis. It is concluded that activation of LPO processes and the decrease of antioxidant defense produce a noticeable destructive effect on the integrity of the red blood cell membrane. They also influence the development of hemolysis.
对10例接受血液透析（HD）治疗的慢性肾衰竭（CRF）患者进行了检查。所有患者均表现出明显的贫血。红细胞计数平均为（2.7±0.2）×10¹²/L，血红蛋白浓度为79.5±5.6 g/L，血细胞比容为23.2±1.8%。患者红细胞中丙二醛的含量远高于对照组，分别为132%（每1 ml溶血产物）、134%（每1 mg蛋白质）（p<0.05）。患者红细胞中的过氧化氢酶和谷胱甘肽过氧化物酶活性与对照组无差异。超氧化物歧化酶活性比献血者降低了43%（p<0.001）。作者回顾了血液透析的CRF患者红细胞脂质过氧化（LPO）及抗氧化防御降低的可能机制。得出的结论是，LPO过程的激活和抗氧化防御的降低对红细胞膜的完整性产生了明显的破坏作用。它们还影响溶血的发生。
