Kornberg A, Matzner Y, Polliack A
Isr J Med Sci. 1978 Dec;14(12):1242-6.
This report deals with an unusual case of a patient with four primary tumors. Hodgkin's disease developed in an elderly woman 21 years after she was treated for carcinoma of the breast by surgery and irradiation. Chronic lymphocytic leukemia and a liposarcoma of the soft tissues developed two years after the appearance of Hodgkin's lymphoma. The coexistence of four primary tumors in the same patient is rare; the simultaneous occurrence of Hodgkin's lymphoma and lymphocytic leukemia is in itself a rare association and is probably a chance finding. The development of these neoplasias may in some way relate to the radiotherapy given to the patient.
本报告涉及一名患有四种原发性肿瘤的罕见病例。一名老年女性在接受乳腺癌手术和放疗21年后患上了霍奇金病。在霍奇金淋巴瘤出现两年后，又患上了慢性淋巴细胞白血病和软组织脂肪肉瘤。同一患者同时存在四种原发性肿瘤实属罕见；霍奇金淋巴瘤和淋巴细胞白血病同时出现本身就是一种罕见的关联，很可能是偶然发现。这些肿瘤的发生可能在某种程度上与该患者接受的放疗有关。
