Vandervelde E M
J Clin Pathol. 1978 Dec;31(12):1140-2. doi: 10.1136/jcp.31.12.1140.
The value of testing for core antibody (anti HBc) in acute hepatitis was assessed in 503 patients. All hepatitis B surface antigen (HBsAg) positive patients tested were also anti HBc positive. Of the 110 HBsAg negative, anti HBc positive patients, 32 were found to have surface antibody, indicating previous infection with hepatitis B virus (HBV). Of the remaining 78 patients in whom anti HBc alone was detectable, follow-up specimens were received from 28 and, of these, 21 were then found to be anti HBc negative. Thus in acute hepatitis non-specific transient reactions to core antigen may appear, and the presence of anti HBc alone cannot be considered adequate evidence for a diagnosis of HBV infection.
对503例急性肝炎患者进行了核心抗体（抗-HBc）检测的价值评估。所有检测的乙肝表面抗原（HBsAg）阳性患者抗-HBc也呈阳性。在110例HBsAg阴性、抗-HBc阳性患者中，32例发现有表面抗体，提示既往感染过乙肝病毒（HBV）。在其余仅可检测到抗-HBc的78例患者中，收到了28例的随访标本，其中21例后来发现抗-HBc阴性。因此，在急性肝炎中可能会出现对核心抗原的非特异性短暂反应，仅抗-HBc阳性不能被视为诊断HBV感染的充分证据。
