Cohen B J, Cossart Y E
J Clin Pathol. 1977 Aug;30(8):709-13. doi: 10.1136/jcp.30.8.709.
Hepatitis B core antigen (HBcAg) was prepared from human liver tissue and used in an immunoelectro-osmophoresis screening test to detect antibody to HBcAg (anti-HBc) in patients with evidence of liver disease and in blood donors. With the exception of two immunosuppressed HBsAg carriers, anti-HBc was found in all cases of hepatitis B infection even when HBsAg was detectable only by radioimmunoassay. Non-specific reactions were observed in 'non-B' hepatitis but, in spite of this problem, antib-HBc screening was considered a useful addition to routine tests in the clinical hepatitis laboratory.
乙肝核心抗原（HBcAg）从人肝组织中制备，并用于免疫电渗电泳筛查试验，以检测肝病患者和献血者中针对HBcAg的抗体（抗-HBc）。除两名免疫抑制的HBsAg携带者外，在所有乙肝感染病例中均发现了抗-HBc，即使HBsAg仅通过放射免疫测定法才可检测到。在“非B型”肝炎中观察到非特异性反应，尽管存在这个问题，但抗-HBc筛查仍被认为是临床肝炎实验室常规检测的有益补充。
