Malheiros S M, Brucki S M, Gabbai A A, Bertolucci P H, Juliano Y, Carvalho A C, Buffolo E
Department of Neurology, Statistics Escola Paulista de Medicina, São Paulo, Brazil.
Acta Neurol Scand. 1995 Sep;92(3):256-60. doi: 10.1111/j.1600-0404.1995.tb01698.x.
The neurological complications of coronary artery surgery with cardiopulmonary bypass (CPB) have been extensively studied, but to our knowledge those without CPB (NCPB) have not been defined.
PATIENTS & METHODS: We prospectively examined 81 patients, before and up to seven days after surgery, to compare the neurological morbidity between patients subjected to coronary artery bypass graft (CABG) surgery with and without CPB. We analyzed demographic variables, risk factors and neurological examination including neuropsychological (NPS) tests using chi-square and non-parametric analysis (Mann-Whitney and Kruskal-Wallis).
Forty-eight patients (34M; median age = 62 yrs; median number of grafts = 3 and median total surgery duration = 300 min) operated with CPB and 33 without CPB (23M; median age = 64 yrs; median number of grafts = 2 and median total surgery duration = 240 min) differed only in relation to number of grafts (p = 0.0001) and surgery duration (p = 0.0001).
We found no difference in early neurological outcome in patients subjected to CABG with or without CPB.
体外循环（CPB）冠状动脉手术的神经并发症已得到广泛研究，但据我们所知，非体外循环（NCPB）冠状动脉手术的神经并发症尚未明确。
我们前瞻性地检查了81例患者，在手术前及术后7天内，比较接受体外循环冠状动脉搭桥术（CABG）和非体外循环冠状动脉搭桥术患者的神经发病率。我们使用卡方检验和非参数分析（曼-惠特尼检验和克鲁斯卡尔-沃利斯检验）分析人口统计学变量、危险因素和神经检查，包括神经心理学（NPS）测试。
48例接受体外循环手术的患者（34例男性；中位年龄=62岁；中位移植血管数=3根，中位总手术时长=300分钟）和33例未接受体外循环手术的患者（23例男性；中位年龄=64岁；中位移植血管数=2根，中位总手术时长=240分钟）仅在移植血管数（p=0.0001）和手术时长（p=0.0001）方面存在差异。
我们发现接受体外循环或非体外循环CABG手术的患者早期神经结局无差异。
