Heikkilä J T, Aho H J, Yli-Urpo A, Happonen R P, Aho A J
University of Turku, Department of Surgery, Turku University Central Hospital, Finland.
Acta Orthop Scand. 1995 Oct;66(5):463-7. doi: 10.3109/17453679508995588.
We examined new bone formation after filling cancellous bone defects with bioactive glass (BG) in granular form. Cylindrical defects in the trochanter area of 18 rabbit femora were filled with BG granules (diameter 600-830 microns) and compared with similar defects filled with morcellized autogenous bone. New bone formation and surface reaction of BG particles were evaluated by light microscopy, histomorphometry, and scanning electron microscopy. The chemical profile at the bone- material interface was studied by energy dispersive x-ray analysis (EDXA). In the BG group, 41, 32, and 38 percent of the defects were filled with new bone after 3, 6, and 12 weeks, respectively. The corresponding figures for the autogenous bone group were 36, 29, and 34 percent. The thickness of the reaction layer on the glass surface increased from 82 to 163 microns during the observation periods. An intimate contact without intervening soft tissue between new bone lamellae and BG granules was a constant finding. EDXA showed a chemical continuum between the granules and the new bone. No adverse reactions related to BG were observed. BG is a promising material for filling cancellous bone defects.
我们研究了用颗粒状生物活性玻璃（BG）填充松质骨缺损后的新骨形成情况。在18只兔股骨转子区制造圆柱形缺损，用BG颗粒（直径600 - 830微米）填充，并与填充碎自体骨的类似缺损进行比较。通过光学显微镜、组织形态计量学和扫描电子显微镜评估BG颗粒的新骨形成和表面反应。通过能量色散X射线分析（EDXA）研究骨-材料界面的化学特征。在BG组中，3周、6周和12周后分别有41%、32%和38%的缺损被新骨填充。自体骨组的相应数字分别为36%、29%和34%。在观察期间，玻璃表面反应层的厚度从82微米增加到163微米。新骨板层与BG颗粒之间紧密接触且无中间软组织是一个持续的发现。EDXA显示颗粒与新骨之间存在化学连续性。未观察到与BG相关的不良反应。BG是一种有前景的填充松质骨缺损的材料。
