Yamazaki Y, Miyamoto S, Hayamizu F, Nakagami T, Koide C
Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan.
Nippon Ganka Gakkai Zasshi. 1995 Sep;99(9):1017-21.
We investigated the relationship between visual field defects and some clinical factors in 30 eyes of 30 normal-tension glaucoma (NTG) patients. The static central visual field by the Humphrey field analyzer, diurnal variation of intraocular pressure (diurnal IOP), blood flow velocity of the ophthalmic artery by color Doppler imaging, blood flow volume of digital tissue by laser flowmetry, and systemic blood pressure (BP) were measured after rinsing out the anti-glaucoma drug for one month. Mean deviation (MD) calculated by the Humphrey STATPAC program as an index of visual field defect, was correlated to the Pourcelot index (RI) of ophthalmic arterial blood flow and magnitude of diurnal IOP. In multiple regression analysis, the multiple correlation coefficient was 0.79 and the coefficient of determination was 0.62. RI, systolic BP, magnitude of diurnal IOP, and the refraction and mean of diurnal IOP were used in the multiple correlation model as factors significantly related to MD. These results suggest that both IOP and some clinical factors may contribute to the visual field defects of NTG.
我们对30例正常眼压性青光眼（NTG）患者的30只眼睛的视野缺损与一些临床因素之间的关系进行了研究。在停用抗青光眼药物1个月后，使用汉弗莱视野分析仪测量静态中心视野、眼压的日波动（昼夜眼压）、彩色多普勒成像测量眼动脉血流速度、激光血流仪测量指端组织血流量以及测量全身血压（BP）。由汉弗莱STATPAC程序计算得出的平均偏差（MD）作为视野缺损的指标，与眼动脉血流的普尔塞洛指数（RI）和昼夜眼压幅度相关。在多元回归分析中，复相关系数为0.79，决定系数为0.62。在多元相关模型中，RI、收缩压、昼夜眼压幅度以及屈光不正和昼夜眼压平均值被用作与MD显著相关的因素。这些结果表明，眼压和一些临床因素可能都与NTG的视野缺损有关。
