一名4岁儿童的Vogt-小柳-原田综合征
Vogt-Koyanagi-Harada syndrome in a 4-year old child.
作者信息
Cunningham E T, Demetrius R, Frieden I J, Emery H M, Irvine A R, Good W V
机构信息
Department of Ophthalmology, University of California, San Francisco, School of Medicine, USA.
出版信息
Am J Ophthalmol. 1995 Nov;120(5):675-7. doi: 10.1016/s0002-9394(14)72219-6.
PURPOSE
We studied a case of severe bilateral Vogt-Koyanagi-Harada syndrome in a 4-year-old boy.
METHODS
We evaluated the patient's clinical course.
RESULTS
The patient had severe bilateral, nongranulomatous uveitis and mild uveitic glaucoma. Initial examination and laboratory evaluation failed to provide a diagnosis. The patient subsequently developed areas of vitiligo, alopecia, and poliosis, suggesting the diagnosis of Vogt-Koyanagi-Harada syndrome. This diagnosis was confirmed by the eventual development of bilateral neurosensory retinal detachments. Vision was lost despite aggressive therapy with corticosteroids and chlorambucil.
CONCLUSION
Although uncommon, Vogt-Koyanagi-Harada may affect young children, and may be severe.
目的
我们研究了一名4岁男孩患严重双侧Vogt-小柳原田综合征的病例。
方法
我们评估了该患者的临床病程。
结果
该患者患有严重双侧非肉芽肿性葡萄膜炎和轻度葡萄膜炎性青光眼。初次检查和实验室评估未能明确诊断。该患者随后出现白癜风、脱发和白发区，提示Vogt-小柳原田综合征的诊断。双侧神经感觉性视网膜脱离的最终出现证实了这一诊断。尽管使用皮质类固醇和苯丁酸氮芥进行了积极治疗，但视力仍丧失。
结论
虽然不常见，但Vogt-小柳原田综合征可能影响幼儿，且病情可能严重。
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