Baer J S, Novick N J, Hummel-Schluger A O
Department of Psychology, University of Washington, Seattle 98195-1525, USA.
Alcohol Clin Exp Res. 1995 Aug;19(4):955-60. doi: 10.1111/j.1530-0277.1995.tb00973.x.
Two studies examined task persistence after alcohol consumption among young adult offspring of alcoholics [children of alcoholics (COAs)] and young adult offspring of nonalcoholics (NonCOAs). In study I, heavy drinking college seniors (n = 294) participated in a laboratory alcohol challenge in the context of a baseline assessment for a longitudinal study. Subjects completed a computerized administration of the Matching Familiar Figures Test in two halves: the first half sober, and the second half approximately 50 min after consuming a 0.8 ml/kg body weight dose of ethanol. COAs demonstrated significantly greater acceleration of response latencies after consumption of alcohol compared with NonCOAs. In study II, moderate-to-heavy drinking volunteers (n = 149) were recruited for a one-time laboratory alcohol challenge, and completed a circle-tracing task three times approximately 50 min after consuming a 0.8 ml/kg body weight dose of ethanol. COAs displayed significantly less persistence on the second and third circle-tracing trials compared with NonCOAs. Data are discussed in relation to models of impulsivity and differential alcohol sensitivity among COAs.
两项研究考察了酗酒者的成年子女（酗酒者子女，即COAs）和非酗酒者的成年子女（非酗酒者子女，即NonCOAs）在饮酒后任务坚持性的情况。在研究I中，大量饮酒的大四学生（n = 294）在一项纵向研究的基线评估背景下参与了一项实验室酒精激发试验。受试者分两部分完成了电脑化的匹配熟悉图形测验：前半部分保持清醒，后半部分在摄入0.8毫升/千克体重剂量的乙醇后约50分钟进行。与NonCOAs相比，COAs在饮酒后反应潜伏期的加速明显更大。在研究II中，招募了中度至大量饮酒的志愿者（n = 149）进行一次性的实验室酒精激发试验，并在摄入0.8毫升/千克体重剂量的乙醇后约50分钟三次完成画圈任务。与NonCOAs相比，COAs在第二次和第三次画圈试验中的坚持性明显更低。结合COAs中的冲动性模型和酒精敏感性差异对数据进行了讨论。
