Lex B W, Rhoades E M, Teoh S K, Mendelson J H, Greenwald N E
Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02178.
Drug Alcohol Depend. 1994 Apr;35(2):95-105. doi: 10.1016/0376-8716(94)90116-3.
Women with (FHP) and without (FHN) family histories of alcoholism received either 0.56 g/kg alcohol or an isocaloric placebo in a repeated measures group design. Subjects performed a divided attention task and gave subjective ratings of 12 alcohol effects over a 3-h interval. After comparable doses of alcohol, 7 FHP and 10 FHN women had comparable ascending (blood alcohol levels) BALs. BALs peaked earlier for FHP women and then steadily declined. FHP women had a concomitant increase in visual search response times 30 min after alcohol. In contrast, scores on a simultaneously presented compensatory tracking task were virtually identical for the 7 FHP and 10 FHN women after alcohol and for the 8 FHP and 10 FHN women after placebo. After alcohol the FHP and FHN women had 7 out of 12 significantly different subjective ratings of alcohol responses. FHP women had lower subjective responses to alcohol and lower BALs, but their subjective responses were more strongly correlated with BALs. Our findings for women studied in a group design confirm the lower magnitude of subjective responses reported for pair-matched FHP men following comparable doses of alcohol in within-subjects and between-subjects designs in other laboratories.
有（FHP）和无（FHN）酗酒家族史的女性在重复测量组设计中接受了0.56克/千克酒精或等热量安慰剂。受试者执行一项分散注意力任务，并在3小时内对12种酒精效应进行主观评分。在摄入相当剂量的酒精后，7名有FHP家族史和10名无FHP家族史的女性的血液酒精浓度（BALs）上升情况相当。有FHP家族史的女性BALs达到峰值的时间更早，然后稳步下降。有FHP家族史的女性在饮酒30分钟后视觉搜索反应时间随之增加。相比之下，在饮酒后，7名有FHP家族史和10名无FHP家族史的女性以及在服用安慰剂后8名有FHP家族史和10名无FHP家族史的女性在同时进行的补偿跟踪任务中的得分几乎相同。饮酒后，有FHP家族史和无FHP家族史的女性在12种酒精反应主观评分中有7种存在显著差异。有FHP家族史的女性对酒精的主观反应较低，BALs也较低，但她们的主观反应与BALs的相关性更强。我们在组设计中对女性的研究结果证实了在其他实验室的受试者内和受试者间设计中，在摄入相当剂量酒精后，配对匹配的有FHP家族史男性报告的主观反应程度较低。
