Richey K A, McNamara J A, Wilmot J J, Garn S M, Loos P J
Department of Community Dentistry, Eastman Dental Center, Rochester, New York, USA.
Angle Orthod. 1995;65(4):293-300. doi: 10.1043/0003-3219(1995)065<0293:ADCICW>2.0.CO;2.
Recombinant human growth hormone (rhGH) increases stature when administered to non-GH-deficient idiopathic short statured children. The aims of this investigation were to determine pretreatment arch dimensions of short statured children (height > or = 2 S.D. below mean for age) and to evaluate their response to rhGH administration by measuring arch-dimensional changes over 5 years of rhGH treatment. Dental casts of 28 short subjects (22 male, 6 female) and of age/gender-matched controls of normal stature were analyzed using a digital imaging system. Four measures of arch width and one of arch depth were calculated for each maxillary and mandibular cast. Subjects receiving orthodontic care were eliminated from the study at the initiation of treatment. Z-scores were calculated to allow for pooling of data. Prior to rhGH treatment, all arch dimensions of the short statured subjects were smaller than the controls, with the exception of mandibular arch depth. Arch dimensions of the rhGH subjects did increase with the continued administration of rhGH. The control group also showed a significant trend for the arch dimensions to increase over time. The influence of rhGH treatment on arch dimensional changes over time remains equivocal based on the results of this investigation.
重组人生长激素（rhGH）用于非生长激素缺乏的特发性身材矮小儿童时可增加身高。本研究的目的是确定身材矮小儿童（身高≥低于年龄均值2个标准差）治疗前的牙弓尺寸，并通过测量rhGH治疗5年期间牙弓尺寸的变化来评估他们对rhGH治疗的反应。使用数字成像系统分析了28名身材矮小受试者（22名男性，6名女性）以及年龄和性别匹配的正常身材对照者的牙模。为每个上颌和下颌牙模计算了四项牙弓宽度测量值和一项牙弓深度测量值。接受正畸治疗的受试者在治疗开始时被排除在研究之外。计算Z分数以便汇总数据。在rhGH治疗前，身材矮小受试者的所有牙弓尺寸均小于对照组，但下颌牙弓深度除外。rhGH受试者的牙弓尺寸确实随着rhGH的持续给药而增加。对照组也显示出牙弓尺寸随时间增加的显著趋势。基于本研究结果，rhGH治疗对牙弓尺寸随时间变化的影响仍不明确。
