Ito R K, Vig K W, Garn S M, Hopwood N J, Loos P J, Spalding P M, Deputy B S, Hoard B C
University of Michigan, Ann Arbor.
Am J Orthod Dentofacial Orthop. 1993 Apr;103(4):358-64. doi: 10.1016/0889-5406(93)70017-I.
The purpose of this preliminary study was to evaluate tooth formation in children with idiopathic short stature, before and during treatment with recombinant growth hormone (rhGH). Twenty-nine short-statured children ages 6 to 13 years were assigned into two treatment groups, an "experimental" group (n = 18), which received rhGH, and a "control" group (n = 11), which was observed for 1 year before commencing rhGH treatment. Clinical and radiographic records were obtained at the initial, year 1, and year 2 visits. Tooth formation and stature were assessed by calculating Z-scores, appropriate for the age and gender of each child. Delta-Z scores, which measure the change in Z-score over time, were also calculated between annual visits. Height was measured and recorded every 3 months, and Z-score statural norms for age and gender were derived from the 1977 National Center for Health Services national probability sampling. Tooth formation standards were derived from Moorrees et al. A matched control sample for tooth development was derived from untreated children. Tooth formation was initially delayed although the degree of reduction in stature exceeded the initial degree of delay in tooth formation. During this 2-year study, rhGH therapy had a significant influence on acceleration or gain in stature, but did not have a significant influence on tooth formation.
这项初步研究的目的是评估特发性身材矮小儿童在接受重组生长激素（rhGH）治疗前及治疗期间的牙齿发育情况。29名6至13岁的身材矮小儿童被分为两个治疗组，一个“实验组”（n = 18），接受rhGH治疗，另一个“对照组”（n = 11），在开始rhGH治疗前观察1年。在初次就诊、第1年和第2年就诊时获取临床和影像学记录。通过计算适合每个儿童年龄和性别的Z分数来评估牙齿发育和身高。还计算了年度就诊之间的Delta-Z分数，以衡量Z分数随时间的变化。每3个月测量并记录一次身高，年龄和性别的Z分数身高标准来自1977年国家卫生服务中心的全国概率抽样。牙齿发育标准来自穆里斯等人的研究。牙齿发育的匹配对照样本来自未治疗的儿童。牙齿发育最初延迟，尽管身高降低的程度超过了牙齿发育最初延迟的程度。在这项为期2年的研究中，rhGH治疗对身高的加速增长或增加有显著影响，但对牙齿发育没有显著影响。
