Perino L J, Wittum T E, Ross G S
Department of Veterinary and Biomedical Sciences, University of Nebraska, Clay Center, USA.
Am J Vet Res. 1995 Sep;56(9):1144-8.
In an attempt to identify important predictors of failure of passive immunoglobulin transfer (< 800 mg of IgG/dl), identify calves with failure of passive immunoglobulin transfer, and determine the effects of a colostrum supplement, blood samples were collected from 263 calves at postpartum hours 10 and 24. Calves of dams diagnosed with mastitis had lower mean plasma protein and IgG concentrations at 10 (P < 0.05) and 24 (P < 0.01) hours. Plasma protein and IgG concentrations were similar for single and twin calves at 10 hours, but IgG concentration at 24 hours was higher (P < 0.01) in twin calves. Calves born to dams that had dystocia had numerically lower mean plasma protein and IgG concentrations than did calves born to dams that had normal delivery. However, observed differences were small and, after adjustment for other important factors, these differences were not significant. Age of dam was associated with plasma protein (P < 0.05) and IgG (P < 0.10) concentrations at 10 hours, but had no effect at 24 hours. Plasma protein and IgG concentrations decreased as calves were born later in the calving season, although the association of birth date with IgG concentration at 24 hours was marginal (P = 0.07). Calf sex, dam body condition score, and birth weight were not related to plasma protein or IgG values. The sensitivity and specificity of a cutoff value of 4.8 g of protein/dl of plasma, measured at 10 hours, for diagnosing failure of passive immunoglobulin transfer at 10 hours were 78 and 94%, and for diagnosing failure of passive immunoglobulin transfer at 24 hours were 88 and 73%, respectively. A colostrum supplement administered to calves with low plasma protein concentration at 10 hours had no effect on plasma protein or IgG values at 24 hours or on preweaning morbidity and mortality.
为了确定被动免疫球蛋白转移失败（<800mg IgG/dl）的重要预测因素、识别被动免疫球蛋白转移失败的犊牛，并确定初乳补充剂的效果，在产后10小时和24小时从263头犊牛采集血样。诊断为乳腺炎的母牛所产犊牛在10小时（P<0.05）和24小时（P<0.01）时的平均血浆蛋白和IgG浓度较低。单胎和双胎犊牛在10小时时血浆蛋白和IgG浓度相似，但双胎犊牛在24小时时的IgG浓度较高（P<0.01）。难产母牛所产犊牛的平均血浆蛋白和IgG浓度在数值上低于顺产母牛所产犊牛。然而，观察到的差异较小，在对其他重要因素进行调整后，这些差异不显著。母牛年龄与10小时时的血浆蛋白（P<0.05）和IgG（P<0.10）浓度相关，但在24小时时没有影响。随着犊牛在产犊季节后期出生，血浆蛋白和IgG浓度降低，尽管出生日期与24小时时的IgG浓度的关联很微弱（P=0.07）。犊牛性别、母牛体况评分和出生体重与血浆蛋白或IgG值无关。在10小时测量时，血浆蛋白浓度为4.8g/dl作为诊断10小时时被动免疫球蛋白转移失败的临界值，其敏感性和特异性分别为78%和94%，诊断24小时时被动免疫球蛋白转移失败的敏感性和特异性分别为88%和73%。对10小时时血浆蛋白浓度低的犊牛给予初乳补充剂，对24小时时的血浆蛋白或IgG值以及断奶前发病率和死亡率没有影响。
