Bensaid P, Vaillant L, Estève E, Machet M C, Machet L, Lorette G
Service de Dermatologie, CHU Trousseau, Tours.
Ann Dermatol Venereol. 1995;122(3):84-9.
Although cutaneous photosensitivity is one of the major criteria used for the diagnosis of systemic lupus erythematosus, this criterion is not precise.
To evaluate the interest of photobiological exploration in patients with cutaneous lupus erythematosus, and to compare the results to clinical photosensitivity.
Nineteen patients consecutively seen in one year, have been tested using a standardized method.
Clinical photosensitivity was present in 16 cases. The clinical presentation of cutaneous disease was classified in 3 groups: acute, subacute, and chronic. One patient with no history of photosensitivity had positive photobiological tests, and five patients had negative tests though they experienced clinical photosensitivity. Positive phototests with UVA and UVB were present in 6/8 subacute lupus cases, 3/6 acute lupus cases, 3/5 chronic lupus cases. Histological aspect of cutaneous biopsies from phototest was not characteristic of lupus. Minimal erythematous doses was comparable in lupus group and in controls. No correlation between positivity of phototests and the presence of systemic involvement or anti-Ro/SSA antibodies was established.
Phototesting is useful to assess photosensitivity in lupus patients.
尽管皮肤光敏性是用于诊断系统性红斑狼疮的主要标准之一，但该标准并不精确。
评估皮肤型红斑狼疮患者光生物学检测的价值，并将结果与临床光敏性进行比较。
对一年内连续就诊的19例患者采用标准化方法进行检测。
16例患者存在临床光敏性。皮肤疾病的临床表现分为3组：急性、亚急性和慢性。1例无光敏史患者的光生物学检测呈阳性，5例患者虽有临床光敏性但检测结果为阴性。8例亚急性狼疮患者中有6例UVA和UVB光试验呈阳性，6例急性狼疮患者中有3例阳性，5例慢性狼疮患者中有3例阳性。光试验皮肤活检的组织学表现并非狼疮的特征性表现。狼疮组和对照组的最小红斑量相当。光试验阳性与系统性受累或抗Ro/SSA抗体的存在之间未建立相关性。
光试验有助于评估狼疮患者的光敏性。
