pH对新型β-内酰胺酶及β-内酰胺酶抑制剂针对这些β-内酰胺酶活性的影响。
Effect of pH on activities of novel beta-lactamases and beta-lactamase inhibitors against these beta-lactamases.
作者信息
Ohsuka S, Arakawa Y, Horii T, Ito H, Ohta M
机构信息
Department of Bacteriology, Nagoya University School of Medicine, Japan.
出版信息
Antimicrob Agents Chemother. 1995 Aug;39(8):1856-8. doi: 10.1128/AAC.39.8.1856.
Abstract
The effects of acidic conditions on activities of seven beta-lactamases--TEM-1 (class A), KOXY (class A), IMP-1 (class B), AmpC (class C), MOX-1 (class C), OXA-5 (class D), and PSE-2 (class D)--and their inhibitors were measured. The enzymatic activities of KOXY, IMP-1, and MOX-1 at pH 5.8 were slightly lower than those at pH 7.5. However, the activities of PSE-2 and OXA-5 were greatly reduced at pH 5.8. All of the beta-lactamase inhibitors tested had poorer inhibitory activities at pH 5.8 than at pH 7.5 except clavulanic acid for TEM-1.
摘要
测定了酸性条件对7种β-内酰胺酶（TEM-1（A类）、KOXY（A类）、IMP-1（B类）、AmpC（C类）、MOX-1（C类）、OXA-5（D类）和PSE-2（D类））及其抑制剂活性的影响。KOXY、IMP-1和MOX-1在pH 5.8时的酶活性略低于pH 7.5时的活性。然而，PSE-2和OXA-5在pH 5.8时的活性大大降低。除TEM-1的克拉维酸外，所有测试的β-内酰胺酶抑制剂在pH 5.8时的抑制活性均低于pH 7.5时的抑制活性。
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