Paganini-Hill A
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, USA.
Arch Intern Med. 1995 Nov 27;155(21):2325-9.
Several studies have demonstrated a relationship between tooth loss and alveolar residual ridge resorption and systemic osteoporosis. The recognized benefit of estrogen replacement therapy (ERT) in postmenopausal osteoporosis prompted review of the Leisure World Cohort Study regarding the effects of ERT on tooth loss and the need for dentures in older women.
The Leisure World Cohort, established in 1981, comprises 13,979 residents (8877 women) of a retirement community. Of the 5935 cohort women alive in 1992, 3921 returned a dental survey with sufficient information to analyze relationships with ERT as reported on the original baseline questionnaire.
After adjusting for age, tooth loss and rates of edentia were significantly lower in estrogen users than in nonusers (relative risk for edentia, 0.64; 95% confidence interval, 0.51 to 0.79). The proportion of women with edentia decreased with increasing duration of ERT. Denture wearing was also less common in estrogen users than in nonusers (relative risk, 0.81; 95% confidence interval, 0.71 to 0.93) and decreased with increasing duration of ERT.
Estrogen replacement therapy may be beneficial in preventing tooth loss and the need for dentures in older women.
多项研究表明牙齿缺失与牙槽嵴残余吸收及全身性骨质疏松之间存在关联。雌激素替代疗法（ERT）在绝经后骨质疏松症方面已被认可的益处促使对休闲世界队列研究进行回顾，以探讨ERT对老年女性牙齿缺失及义齿需求的影响。
1981年建立的休闲世界队列包括一个退休社区的13979名居民（8877名女性）。在1992年仍在世的5935名队列女性中，3921人返回了一份牙科调查问卷，其中有足够信息可用于分析与原始基线问卷中所报告的ERT之间的关系。
在调整年龄后，雌激素使用者的牙齿缺失和无牙率显著低于非使用者（无牙的相对风险为0.64；95%置信区间为0.51至0.79）。无牙女性的比例随着ERT持续时间的增加而降低。雌激素使用者佩戴义齿的情况也比非使用者少见（相对风险为0.81；95%置信区间为0.71至0.93），并且随着ERT持续时间的增加而减少。
雌激素替代疗法可能有助于预防老年女性牙齿缺失及义齿需求。
