Logeais Y, Roussin R, Langanay T, Leguerrier A, Rioux C, Chaperon J, Corbineau H, Lelong B, Sevray B, Valla J
Clinique chirurgicale cardiovasculaire et thoracique, hôpital Pontchaillou, Rennes.
Arch Mal Coeur Vaiss. 1995 Feb;88(2):189-95.
From 1978 to 1992, 200 patients aged 80 to 90 (average 82.16 +/- 2.04 years) with calcific aortic stenosis, underwent isolated aortic valve replacement (187 cases, 93.5%), or associated with coronary bypass surgery (12 cases, 6%), or mitral valve replacement (MVR) (1 case, 0.5%), or surgery of the ascending aorta (4 cases, 2%). These 200 patients represented 7.4% of the 2,716 cases of aortic stenosis operated during the same period. One hundred and forty-eight patients (74%) were in NYHA classes III or IV. The operative mortality was 11.5% (23 patients) and the average hospital stay in the surgical department was 12.7 days (4.83%). The follow-up of the 177 patients who were discharged from hospital was complete (100%) with an average of 2.8 years +/- 2.1 (1 month to 10.6 years). Forty-nine secondary fatalities were observed (28%). Of the 128 survivors at the end of the study, 127 (98.6%) were in the NYHA classes I or II. The actuarial 1, 3 and 5 year survivals were 81.7, 74.8 and 57.1%, respectively. The survival curve of the operated patients was identical to subjects of the same age without aortic stenosis. Despite the high but acceptable operative risk due to the age, valvular replacement surgery is justified by the double benefit of increased longivity and improved quality of life.
1978年至1992年期间,200例年龄在80至90岁(平均82.16±2.04岁)的钙化性主动脉瓣狭窄患者接受了单纯主动脉瓣置换术(187例,93.5%),或联合冠状动脉搭桥手术(12例,6%),或二尖瓣置换术(MVR)(1例,0.5%),或升主动脉手术(4例,2%)。这200例患者占同期2716例主动脉瓣狭窄手术病例的7.4%。148例患者(74%)属于纽约心脏协会(NYHA)心功能分级III或IV级。手术死亡率为11.5%(23例患者),外科科室的平均住院时间为12.7天(4.83%)。对177例出院患者的随访完整率为100%,平均随访时间为2.8年±2.1年(1个月至10.6年)。观察到49例继发性死亡(28%)。在研究结束时的128例幸存者中,127例(98.6%)属于NYHA心功能分级I或II级。1年、3年和5年的精算生存率分别为81.7%、74.8%和57.1%。手术患者的生存曲线与同龄无主动脉瓣狭窄的受试者相同。尽管由于年龄因素手术风险较高但仍可接受,但瓣膜置换手术因延长寿命和改善生活质量的双重益处而具有合理性。