• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The US3 protein kinase of herpes simplex virus type 2 is associated with phosphorylation of the UL12 alkaline nuclease in vitro.

作者信息

Daikoku T, Yamashita Y, Tsurumi T, Nishiyama Y

机构信息

Laboratory of Virology, Nagoya University School of Medicine, Japan.

出版信息

Arch Virol. 1995;140(9):1637-44. doi: 10.1007/BF01322537.

DOI:10.1007/BF01322537
PMID:7487495
Abstract

Herpes simplex virus type 2 (HSV-2) gene US3 encodes a serine-threonine protein kinase. We previously described the isolation of a US3-inactivated mutant which is able to replicate in Vero cells but not in murine macrophages. To learn more about the biological role of the US3 protein kinase, we have sought to identify the target proteins of the enzyme. Studies of in vitro phosphorylation with extracts of infected cells demonstrate that the US3 protein kinase is involved in phosphorylation of the UL12 alkaline nuclease in vitro, suggesting that the nuclease is a possible target of the protein kinase.

摘要

相似文献

1
The US3 protein kinase of herpes simplex virus type 2 is associated with phosphorylation of the UL12 alkaline nuclease in vitro.
Arch Virol. 1995;140(9):1637-44. doi: 10.1007/BF01322537.
2
Herpes simplex virus 1 protein kinase Us3 phosphorylates viral envelope glycoprotein B and regulates its expression on the cell surface.单纯疱疹病毒1型蛋白激酶Us3使病毒包膜糖蛋白B磷酸化，并调节其在细胞表面的表达。
J Virol. 2009 Jan;83(1):250-61. doi: 10.1128/JVI.01451-08. Epub 2008 Oct 22.
3
US3 protein kinase of herpes simplex virus type 2 is required for the stability of the UL46-encoded tegument protein and its association with virus particles.2型单纯疱疹病毒的US3蛋白激酶对于UL46编码的被膜蛋白的稳定性及其与病毒颗粒的结合是必需的。
J Gen Virol. 2005 Jul;86(Pt 7):1979-1985. doi: 10.1099/vir.0.80949-0.
4
Roles of Us8A and Its Phosphorylation Mediated by Us3 in Herpes Simplex Virus 1 Pathogenesis.单纯疱疹病毒1型致病过程中Us8A的作用及其由Us3介导的磷酸化作用
J Virol. 2016 May 27;90(12):5622-5635. doi: 10.1128/JVI.00446-16. Print 2016 Jun 15.
5
Phosphorylation of a herpes simplex virus 1 dUTPase by a viral protein kinase, Us3, dictates viral pathogenicity in the central nervous system but not at the periphery.单纯疱疹病毒1型dUTP酶被病毒蛋白激酶Us3磷酸化，决定了病毒在中枢神经系统而非外周的致病性。
J Virol. 2014 Mar;88(5):2775-85. doi: 10.1128/JVI.03300-13. Epub 2013 Dec 18.
6
Identification of a target protein of US3 protein kinase of herpes simplex virus type 2.
J Gen Virol. 1994 Aug;75 ( Pt 8):2065-8. doi: 10.1099/0022-1317-75-8-2065.
7
The product of a 1.9-kb mRNA which overlaps the HSV-1 alkaline nuclease gene (UL12) cannot relieve the growth defects of a null mutant.一种与单纯疱疹病毒1型碱性核酸酶基因（UL12）重叠的1.9kb信使核糖核酸的产物，无法缓解无效突变体的生长缺陷。
Virology. 1996 Jan 15;215(2):152-64. doi: 10.1006/viro.1996.0018.
8
Herpes simplex virus 1-encoded protein kinase UL13 phosphorylates viral Us3 protein kinase and regulates nuclear localization of viral envelopment factors UL34 and UL31.单纯疱疹病毒1型编码的蛋白激酶UL13使病毒的Us3蛋白激酶磷酸化，并调节病毒包膜因子UL34和UL31的核定位。
J Virol. 2006 Feb;80(3):1476-86. doi: 10.1128/JVI.80.3.1476-1486.2006.
9
The herpes simplex virus 1 protein kinase encoded by the US3 gene mediates posttranslational modification of the phosphoprotein encoded by the UL34 gene.由US3基因编码的单纯疱疹病毒1型蛋白激酶介导由UL34基因编码的磷蛋白的翻译后修饰。
J Virol. 1991 Nov;65(11):5757-64. doi: 10.1128/JVI.65.11.5757-5764.1991.
10
Herpes simplex virus protein kinases US3 and UL13 modulate VP11/12 phosphorylation, virion packaging, and phosphatidylinositol 3-kinase/Akt signaling activity.单纯疱疹病毒蛋白激酶US3和UL13调节VP11/12磷酸化、病毒体包装以及磷脂酰肌醇3激酶/蛋白激酶B信号传导活性。
J Virol. 2014 Jul;88(13):7379-88. doi: 10.1128/JVI.00712-14. Epub 2014 Apr 16.

引用本文的文献

1
"Non-Essential" Proteins of HSV-1 with Essential Roles In Vivo: A Comprehensive Review.单纯疱疹病毒 1 中具有重要体内功能的“非必需”蛋白：全面综述。
Viruses. 2020 Dec 23;13(1):17. doi: 10.3390/v13010017.
2
The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity.Rad6/18 泛素复合物与 Epstein-Barr 病毒去泛素化酶 BPLF1 相互作用，并有助于病毒感染力。
J Virol. 2014 Jun;88(11):6411-22. doi: 10.1128/JVI.00536-14. Epub 2014 Mar 26.
3
Varicella-zoster virus open reading frame 66 protein kinase and its relationship to alphaherpesvirus US3 kinases.

本文引用的文献

1
Herpes simplex virus 1 alkaline nuclease is required for efficient egress of capsids from the nucleus.单纯疱疹病毒1型碱性核酸酶是衣壳从细胞核有效释放所必需的。
Virology. 1993 Sep;196(1):146-62. doi: 10.1006/viro.1993.1463.
2
A mutant of herpes simplex virus type 1 in which the UL13 protein kinase gene is disrupted.一种1型单纯疱疹病毒的突变体，其中UL13蛋白激酶基因被破坏。
J Gen Virol. 1993 Mar;74 ( Pt 3):387-95. doi: 10.1099/0022-1317-74-3-387.
3
The pathogenicity of a US3 protein kinase-deficient mutant of herpes simplex virus type 2 in mice.
水痘带状疱疹病毒开放阅读框 66 蛋白激酶及其与α疱疹病毒 US3 激酶的关系。
Curr Top Microbiol Immunol. 2010;342:79-98. doi: 10.1007/82_2009_7.
4
Identification of a physiological phosphorylation site of the herpes simplex virus 1-encoded protein kinase Us3 which regulates its optimal catalytic activity in vitro and influences its function in infected cells.鉴定单纯疱疹病毒1型编码的蛋白激酶Us3的一个生理磷酸化位点，该位点在体外调节其最佳催化活性并影响其在感染细胞中的功能。
J Virol. 2008 Jul;82(13):6172-89. doi: 10.1128/JVI.00044-08. Epub 2008 Apr 16.
5
Identification of proteins phosphorylated directly by the Us3 protein kinase encoded by herpes simplex virus 1.单纯疱疹病毒1型编码的Us3蛋白激酶直接磷酸化的蛋白质的鉴定
J Virol. 2005 Jul;79(14):9325-31. doi: 10.1128/JVI.79.14.9325-9331.2005.
6
Expression and localization of the Epstein-Barr virus-encoded protein kinase.爱泼斯坦-巴尔病毒编码蛋白激酶的表达与定位
J Virol. 2004 Nov;78(22):12140-6. doi: 10.1128/JVI.78.22.12140-12146.2004.
7
Insertions in the gG gene of pseudorabies virus reduce expression of the upstream Us3 protein and inhibit cell-to-cell spread of virus infection.伪狂犬病病毒gG基因的插入会降低上游Us3蛋白的表达，并抑制病毒感染的细胞间传播。
J Virol. 2001 Nov;75(22):10856-69. doi: 10.1128/JVI.75.22.10856-10869.2001.
8
A protein kinase activity associated with Epstein-Barr virus BGLF4 phosphorylates the viral early antigen EA-D in vitro.一种与爱泼斯坦-巴尔病毒BGLF4相关的蛋白激酶活性在体外使病毒早期抗原EA-D磷酸化。
J Virol. 2000 Apr;74(7):3093-104. doi: 10.1128/jvi.74.7.3093-3104.2000.
9
Nuclear accumulation of IE62, the varicella-zoster virus (VZV) major transcriptional regulatory protein, is inhibited by phosphorylation mediated by the VZV open reading frame 66 protein kinase.水痘带状疱疹病毒（VZV）主要转录调节蛋白IE62的核积累受到VZV开放阅读框66蛋白激酶介导的磷酸化作用的抑制。
J Virol. 2000 Mar;74(5):2265-77. doi: 10.1128/jvi.74.5.2265-2277.2000.
10
The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse.水痘带状疱疹病毒的ORF47和ORF66推定蛋白激酶决定了其在SCID-hu小鼠中对人T细胞和皮肤的嗜性。
Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11969-74. doi: 10.1073/pnas.95.20.11969.
2型单纯疱疹病毒US3蛋白激酶缺陷型突变体在小鼠中的致病性。
Arch Virol. 1993;133(3-4):259-73. doi: 10.1007/BF01313767.
4
Purification and biochemical characterization of the protein kinase encoded by the US3 gene of herpes simplex virus type 2.单纯疱疹病毒2型US3基因编码的蛋白激酶的纯化及生化特性分析
Virology. 1993 Dec;197(2):685-94. doi: 10.1006/viro.1993.1644.
5
Identification of a target protein of US3 protein kinase of herpes simplex virus type 2.
J Gen Virol. 1994 Aug;75 ( Pt 8):2065-8. doi: 10.1099/0022-1317-75-8-2065.
6
Role of the nuclear matrix in the growth of herpes simplex virus type 2.核基质在2型单纯疱疹病毒生长中的作用。
Arch Virol. 1983;77(1):27-38. doi: 10.1007/BF01314861.
7
Herpes simplex virus non-structural proteins. IV. Purification of the virus-induced deoxyribonuclease and characterization of the enzyme using monoclonal antibodies.单纯疱疹病毒非结构蛋白。IV. 病毒诱导的脱氧核糖核酸酶的纯化及使用单克隆抗体对该酶的特性鉴定
J Gen Virol. 1983 Oct;64 (Pt 10):2249-60. doi: 10.1099/0022-1317-64-10-2249.
8
Herpes simplex virus 1 protein kinase is encoded by open reading frame US3 which is not essential for virus growth in cell culture.单纯疱疹病毒1型蛋白激酶由开放阅读框US3编码，该开放阅读框对于病毒在细胞培养中的生长并非必需。
J Virol. 1987 Sep;61(9):2896-901. doi: 10.1128/JVI.61.9.2896-2901.1987.
9
Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins.1型和2型单纯疱疹病毒碱性核酸外切酶及重叠蛋白编码基因的特性分析
J Virol. 1986 Mar;57(3):1023-36. doi: 10.1128/JVI.57.3.1023-1036.1986.
10
Identification of the herpes simplex virus protein kinase as the product of viral gene US3.鉴定单纯疱疹病毒蛋白激酶为病毒基因US3的产物。
J Gen Virol. 1987 Oct;68 ( Pt 10):2699-704. doi: 10.1099/0022-1317-68-10-2699.