Tsutsui Y, Nishiyama Y, Yoshida S, Maeno K, Hoshino M
Arch Virol. 1983;77(1):27-38. doi: 10.1007/BF01314861.
Nuclear matrix was prepared from Vero cells infected with herpes simplex virus type 2. In the early stage of infection, both 155K and 110K viral proteins were associated with the nuclear matrix, while in the late stage, 155K protein, presumably a viral capsid protein, was predominantly associated with the matrix. Electron microscopic study showed that empty capsids were bound to the filamentous networks of the nuclear matrix of the late stage. Neither viral DNA nor viral DNA polymerase activity was associated with the nuclear matrix. These results may indicate that the nuclear matrix plays some role in the growth of herpes simplex virus, especially during the morphogenesis.
从感染单纯疱疹病毒2型的非洲绿猴肾细胞中制备核基质。在感染早期，155K和110K病毒蛋白都与核基质相关联，而在晚期，推测为病毒衣壳蛋白的155K蛋白主要与核基质相关联。电子显微镜研究表明，空衣壳与晚期核基质的丝状网络结合。病毒DNA和病毒DNA聚合酶活性均与核基质无关。这些结果可能表明核基质在单纯疱疹病毒的生长中起一定作用，尤其是在形态发生过程中。
