Cooper J F, Foti A G
Natl Cancer Inst Monogr. 1978 Dec(49):235-7.
A solid phase radioimmunoassay for human prostatic acid phosphatase has demonstrated substantially greater biochemical sensitivity than a standard enzymatic method for which p-nitrophenylphosphate was used as substrate. Preliminary data indicate that the radioimmunochemical approach can precisely classify 43% stage I-II and 94% stage III-IV prostate cancers. In contrast, the standard enzymatic methods correctly classified only 9% stage I-II and 46% stage III-IV cancers. It is clinically apparent that a radioimmunochemical approach for the measurement of human prostatic phosphatase may have distinct potential in the clinical diagnosis of prostate cancer.
一种用于检测人前列腺酸性磷酸酶的固相放射免疫分析法，已显示出比以对硝基苯磷酸酯为底物的标准酶法具有更高的生化灵敏度。初步数据表明，放射免疫化学方法能够准确地对43%的I-II期和94%的III-IV期前列腺癌进行分类。相比之下，标准酶法仅能正确分类9%的I-II期和46%的III-IV期癌症。临床上显而易见，采用放射免疫化学方法检测人前列腺磷酸酶在前列腺癌的临床诊断中可能具有显著的潜力。
