Majtán V, Majtánová L
Institute of Preventive and Clinical Medicine, Bratislava, Slovakia.
Arzneimittelforschung. 1995 Sep;45(9):1021-3.
The effect of 2-(dodecanoylamino) ethylalkyldimethyl-ammonium bromides on energy-yielding (respiration) and energy-requiring (biosynthesis of nucleic acids and proteins) processes in Salmonella typhimurium cells was studied. The quaternary ammonium salts represented a homologous series (n = 7). The efficacy of the compounds increased with the prolongation of the alkyl carbon chain up to octyl (C8), where the maximum was noted and then the efficacy decreased. This phenomenon known from the antimicrobial efficacy of these substances (cut-off effect) was shown also by influencing the rate of [14C]adenine and [14C]leucine incorporation and the inhibition of oxygen consumption (endogenous respiration). The tested compounds influencing these processes interfere with the energy metabolism of Salmonella typhimurium cells.
研究了2-（十二烷酰氨基）乙基烷基二甲基溴化铵对鼠伤寒沙门氏菌细胞中能量产生（呼吸作用）和能量需求（核酸和蛋白质生物合成）过程的影响。季铵盐代表一个同系物系列（n = 7）。化合物的功效随着烷基碳链延长至辛基（C8）而增加，在辛基处达到最大值，然后功效降低。这些物质的抗菌功效中已知的这种现象（截止效应），在影响[14C]腺嘌呤和[14C]亮氨酸掺入速率以及抑制氧气消耗（内源性呼吸）方面也表现出来。影响这些过程的受试化合物干扰了鼠伤寒沙门氏菌细胞的能量代谢。
