Jahn H, Osther P J, Nielsen E H, Rasmussen G, Andersen J
Department of Surgery, Odense University Hospital, Denmark.
APMIS. 1995 Sep;103(9):628-34. doi: 10.1111/j.1699-0463.1995.tb01415.x.
An ultrastructural study of the epidermis from eight patients with clinical Paget's disease of the nipple supports the epidermotropic theory. There was no evidence that the Paget's cells originated from keratinocytes. We propose the hypothesis that Paget's cells represent transformed ductal cells, from the subjacent lactiferous ducts of the nipple, which have migrated into the epidermis, either as neoplastic cells or as normal ductal cells with secondary in situ transformation in the epidermis.
对八例临床诊断为乳头佩吉特病患者的表皮进行的超微结构研究支持表皮趋向性理论。没有证据表明佩吉特细胞起源于角质形成细胞。我们提出一个假说，即佩吉特细胞代表来自乳头下方输乳管的转化导管细胞，这些细胞已迁移至表皮，要么作为肿瘤细胞，要么作为在表皮发生继发性原位转化的正常导管细胞。
