糖尿病患者急性心肌梗死发病不存在昼夜节律变化。
Absence of circadian variation in the onset of acute myocardial infarction in diabetic subjects.
作者信息
Fava S, Azzopardi J, Muscat H A, Fenech F F
机构信息
Department of Medicine, St Luke's Hospital, Malta.
出版信息
Br Heart J. 1995 Oct;74(4):370-2. doi: 10.1136/hrt.74.4.370.
OBJECTIVES
To investigate the circadian pattern of acute myocardial infarction in non-insulin-dependent diabetic patients and to compare it with that of controls.
BACKGROUND
Previous studies have shown that there is a circadian variation in the incidence of acute myocardial infarction, but there are few data on diabetic subjects.
METHODS
A hospital based prospective case-control study.
RESULTS
196 diabetic patients and 196 age and sex matched controls were admitted with a diagnosis of acute myocardial infarction during the study period. IN 32 diabetic patients and 38 controls, the time of onset of myocardial infarction was unknown; in 34, 44, 42, and 44 diabetic patients the onset was in the first to fourth quarters respectively (chi 2 = 1.66, NS). The corresponding figures for the controls were 30, 56, 45, and 27 (chi 2 = 13.9, P < 0.005). The difference between the two groups was highly significant (chi 2 = 10.3, P < 0.025).
CONCLUSIONS
Diabetic subjects do not show a significant circadian variation in the onset of acute myocardial infarction.
目的
研究非胰岛素依赖型糖尿病患者急性心肌梗死的昼夜模式，并与对照组进行比较。
背景
先前的研究表明急性心肌梗死的发病率存在昼夜变化，但关于糖尿病患者的数据较少。
方法
一项基于医院的前瞻性病例对照研究。
结果
在研究期间，196例糖尿病患者和196例年龄及性别匹配的对照因急性心肌梗死入院。32例糖尿病患者和38例对照的心肌梗死发病时间未知；34例、44例、42例和44例糖尿病患者的发病分别在第一至四季度（卡方 = 1.66，无显著性差异）。对照组的相应数字为30例、56例、45例和27例（卡方 = 13.9，P < 0.005）。两组之间的差异非常显著（卡方 = 10.3，P < 0.025）。
结论
糖尿病患者急性心肌梗死的发病不存在显著的昼夜变化。
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