Anderson D E, Yingling J E
Pavlov J Biol Sci. 1978 Oct-Dec;13(4):241-5. doi: 10.1007/BF03002260.
The arterial pressure, heart rate, stroke volume, cardiac output and total peripheral resistance of laboratory dogs were monitored continuously before and during a 30 min period in which aversive classical conditioning procedures were applied. The experimental stimulation generated inhibition of behavioral activity ("freezing") together with sustained increases in arterial pressure averaging 30%, and increases in heart rate anc cardiac output of 60-70%. The calculated total peripheral resistance decreased by an average of 20%. The behavioral and cardiovascular responses were sustained during the aversive conditioning period. The results suggest that significant peripheral vasodilation occurred under these conditions which was probably not due to metabolic byproducts of behavioral activity, but probably reflected sympathetic cholinergic effects upon blood vessels in the skeletal muscles. These data document the significance of the skeletal muscle circulation in the total peripheral resistance to blood flow in unanesthetized animals.
在对实验犬施加厌恶经典条件反射程序的30分钟期间及之前，持续监测其动脉压、心率、每搏输出量、心输出量和总外周阻力。实验刺激产生了行为活动抑制（“僵住”），同时动脉压持续升高，平均升高30%，心率和心输出量增加60%-70%。计算得出的总外周阻力平均降低20%。在厌恶条件反射期间，行为和心血管反应持续存在。结果表明，在这些条件下发生了显著的外周血管舒张，这可能不是由于行为活动的代谢副产物所致，而可能反映了交感胆碱能对骨骼肌血管的作用。这些数据证明了骨骼肌循环在未麻醉动物总外周血流阻力中的重要性。
