Anderson D E, Yingling J E, Sagawa K
Am J Physiol. 1979 Mar;236(3):H434-9. doi: 10.1152/ajpheart.1979.236.3.H434.
Cardiovascular activity of chronically instrumented conscious dogs was monitored continuously during daily sessions of rest or of intermittent aversive stimulation. Data analysis of minute-to-minute averages revealed that cardiovascular variables changed in patterns, rather than as isolated independent events. Variations in cardiac output were highly positively correlated with concurrent variations in heart rate in all subjects under both conditions (mean r = +0.93). Variations in heart rate were two to five times as great as stroke volume, which was remarkably constant (coefficient of variation averaged only 4.6%). Variations in mean arterial pressure were consistently correlated with the variations in cardiac output (mean r = + 0.66) and heart rate (mean r = +0.68), but were poorly correlated with the small changes in stroke volume (mean r = -0.17) and total peripheral resistance (mean r = -0.16).
在日常休息或间歇性厌恶刺激期间，对长期植入仪器的清醒犬的心血管活动进行连续监测。对每分钟平均值的数据分析表明，心血管变量呈模式性变化，而非孤立的独立事件。在两种条件下，所有受试动物的心输出量变化与心率的同时变化高度正相关（平均r = +0.93）。心率变化幅度是每搏输出量的两到五倍，每搏输出量非常恒定（变异系数平均仅为4.6%）。平均动脉压变化与心输出量变化（平均r = + 0.66）和心率变化（平均r = +0.68）始终相关，但与每搏输出量的微小变化（平均r = -0.17）和总外周阻力变化（平均r = -0.16）相关性较差。
