Cotter D, Takei N, Farrell M, Sham P, Quinn P, Larkin C, Oxford J, Murray R M, O'Callaghan E
Cluain Mhuire Family Centre, Blackrock, Co Dublin, Ireland.
Schizophr Res. 1995 Aug 15;16(3):233-41. doi: 10.1016/0920-9964(94)e0082-i.
Epidemiological studies point to an association between prenatal exposure to influenza and later schizophrenia. Such studies are consistent with neuropathologic reports demonstrating cytoarchitectural abnormalities in the hippocampus and parahippocampal gyrus suggestive of second trimester developmental anomalies. The hypothesis that prenatal exposure to influenza in the second trimester may induce hippocampal pyramidal cell disarray in mice was investigated. Between days 9-16 of pregnancy, 35 Balb/c mice were intranasally inoculated with either a mouse-adapted or non mouse-adapted pool of Influenza A/Singapore/1/57 (H2N2), and 10 controls were inoculated with normal saline. Offspring were sacrificed on day 21 postpartum. Microscopic examination of the CA1-CA2 junctional areas in the offspring of mice exposed to influenza failed to demonstrate excess pyramidal cell disarray when compared with influenza-free, age matched controls. There was evidence that disarray was greater among those exposed on day 13 of pregnancy. Analyses of the data by sex and severity of maternal infection failed to reveal any significant effects.
流行病学研究表明，产前接触流感与日后患精神分裂症之间存在关联。此类研究与神经病理学报告一致，这些报告显示海马体和海马旁回存在细胞结构异常，提示妊娠中期发育异常。研究了妊娠中期产前接触流感可能导致小鼠海马锥体细胞排列紊乱的假说。在妊娠第9至16天，35只Balb/c小鼠经鼻接种适应小鼠或不适应小鼠的甲型流感病毒A/新加坡/1/57（H2N2）毒株，10只对照小鼠接种生理盐水。产后第21天处死后代。与未接触流感、年龄匹配的对照小鼠相比，对接触流感小鼠后代的CA1-CA2交界区进行显微镜检查，未发现锥体细胞排列紊乱过多。有证据表明，妊娠第13天接触流感的小鼠中，细胞排列紊乱更严重。按性别和母体感染严重程度对数据进行分析，未发现任何显著影响。
