Nishimura A, Ueda S, Takeuchi Y, Sawada T, Kawata M
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
Neuroreport. 1995 Jul 10;6(10):1445-8. doi: 10.1097/00001756-199507100-00021.
The age-related changes of serotonergic fibres and S-100 beta-positive astrocytes in the rat dentate gyrus were examined using immunohistochemistry. A significant reduction in the number of the serotonergic fibres and S-100 beta-positive astrocytes was observed throughout the dentate gyrus of the aged rat. A positive correlation was noted between the decrease of serotonergic fibres and S-100 beta-positive astrocytes in the aged rat dentate gyrus. These findings support the hypothesis that the age-related degeneration of serotonergic fibres in the dentate gyrus is caused by the decrease in serotonergic neurotrophic factor S-100 beta in the astrocytes.
采用免疫组织化学方法检测大鼠齿状回中5-羟色胺能纤维和S-100β阳性星形胶质细胞的年龄相关变化。在老年大鼠整个齿状回中观察到5-羟色胺能纤维和S-100β阳性星形胶质细胞数量显著减少。在老年大鼠齿状回中，5-羟色胺能纤维减少与S-100β阳性星形胶质细胞减少之间存在正相关。这些发现支持以下假说：齿状回中5-羟色胺能纤维的年龄相关退化是由星形胶质细胞中5-羟色胺能神经营养因子S-100β减少所致。
