Perttilä J, Salo M, Peltola O
Department of Anaethesiology, Turku University Central Hospital, Finland.
Perfusion. 1995 Jul;10(4):249-56. doi: 10.1177/026765919501000408.
We compared the effects of a centrifugal pump with those of a roller pump on immune responses in 26 coronary artery bypass surgery patients during cardiopulmonary bypass (CPB). The patients were randomly allocated into a (Biomedicus) centrifugal pump group and a (Stöckert) twin roller pump group. Leucocyte and differential counts; percentages of lymphocyte subpopulations (CD3-, CD4-, CD8-, CD16-, CD20- and CD25-positive lymphocytes) and monocytes (CD14); phytohaemagglutinin-, concanavalin A-, and pokeweed mitogen-induced and unstimulated proliferation of separated lymphocytes; unstimulated and pokeweed mitogen-stimulated production of IgG, IgM, or IgA; and plasma fibronectin, C-reactive protein and serum albumin concentrations were measured preoperatively, immediately before CPB, immediately before aortic declamping and on the first postoperative morning. Significant changes were seen in these variables, but no differences occurred between the groups.
我们比较了离心泵和滚压泵对26例冠状动脉搭桥手术患者在体外循环（CPB）期间免疫反应的影响。患者被随机分为（Biomedicus）离心泵组和（Stöckert）双滚压泵组。检测术前、CPB即将开始前、主动脉阻断即将开始前及术后第一个早晨的白细胞及分类计数；淋巴细胞亚群（CD3-、CD4-、CD8-、CD16-、CD20-和CD25阳性淋巴细胞）和单核细胞（CD14）的百分比；植物血凝素、刀豆蛋白A和商陆有丝分裂原诱导及未刺激的分离淋巴细胞增殖；未刺激及商陆有丝分裂原刺激的IgG、IgM或IgA产生；以及血浆纤维连接蛋白、C反应蛋白和血清白蛋白浓度。这些变量有显著变化，但两组之间无差异。
