Chuchalin A G, Grobova O M, Cherniaev A L, Tatarsky A R, Hoffshir D, Voisin C
Institut of Pulmonology, Moscow, Russia.
Stem Cells. 1995 May;13 Suppl 1:276-82. doi: 10.1002/stem.5530130734.
Cytological analysis of bronchoalveolar lavage (BAL) and x-ray energy dispersive spectrometry of intercellular compounds were evaluated in 19 workers ("liquidators") commissioned to clean and contain the nuclear waste after the Chernobyl catastrophe in comparison with ten control subjects. Results showed a significant increase of neutrophils, small monocyte-like alveolar macrophages (AM) and AM with large black cytoplasmic inclusions. In addition, such mineral elements as Zr, Ce, Pr, Sm, Pa, PU and Cs were detected in AM phagosomes in liquidators. These elements were reported as markers of Chernobyl-type nuclear fuel. It is recognized that BAL gives access to particulate matter present in lung parenchyma. Thus, spectrometric analysis of AM inclusions can provide reliable information about the exposure to inhaled radionuclides seven years after the catastrophe.
对19名在切尔诺贝利灾难后受委托清理和处理核废料的工人（“清理者”）进行了支气管肺泡灌洗（BAL）的细胞学分析以及细胞间化合物的X射线能量色散光谱分析，并与10名对照对象进行了比较。结果显示，中性粒细胞、小型单核细胞样肺泡巨噬细胞（AM）以及含有黑色大细胞质内含物的AM显著增加。此外，在清理者的AM吞噬体中检测到了Zr、Ce、Pr、Sm、Pa、Pu和Cs等矿物元素。这些元素被报告为切尔诺贝利型核燃料的标志物。人们认识到，BAL可以获取肺实质中存在的颗粒物。因此，对AM内含物的光谱分析可以提供灾难发生七年后吸入放射性核素暴露的可靠信息。
