Khandogina E K, Ageĭkin V A, Zvereva S V, Marchenko L F, Mutovin G R, Snigireva G P, Lenskaia R V, Buiankin V M, Shakhtarin V V, Akif'ev A P
Radiats Biol Radioecol. 1995 Sep-Oct;35(5):618-25.
The frequency of chromosome aberrations (CA) was studied in peripheral blood lymphocytes from healthy children and children with thyreopathology living in the city of Klintsy, Bryansk Province (contamination level up to 5 Ci/km2), and two Moscow groups, respectively. We have observed the elevated number of dicentrics and acentric fragments in cell from children with thyreopathology with respect to those from healthy children living in Klintsy. This fact cannot be explained by influence of disease because there was no difference in cytogenetical markers between the groups of healthy children and children with thyreopathology from Moscow. The number of dicentrics was increased in cells from children with high level of internal contamination (more than 400 nCi) living in Krasnaya Gora (15-40 Ci/km2). It is proposed that the internal irradiation is more important for the CA induction. The symmetrical translocation analysis using the method of fluorescence in situ hybridisation (FISH) has shown the absence of this type of aberrations in cells from children with high level of internal irradiation whereas the translocations frequency in cells from control children was (1.1 +/- 0.4) per 1000 cells.
分别对布良斯克州克林齐市（污染水平高达5居里/平方公里）的健康儿童和患有甲状腺疾病的儿童以及两组莫斯科儿童的外周血淋巴细胞中的染色体畸变（CA）频率进行了研究。我们观察到，与生活在克林齐的健康儿童相比，患有甲状腺疾病的儿童细胞中的双着丝粒和无着丝粒片段数量有所增加。这一事实无法用疾病的影响来解释，因为莫斯科的健康儿童组和患有甲状腺疾病的儿童组之间的细胞遗传学标记没有差异。生活在克拉斯纳亚戈拉（15 - 40居里/平方公里）、体内污染水平高（超过400纳居里）的儿童细胞中的双着丝粒数量增加。有人提出，内照射对染色体畸变的诱导更为重要。使用荧光原位杂交（FISH）方法进行的对称易位分析表明，体内照射水平高的儿童细胞中不存在这种类型的畸变，而对照儿童细胞中的易位频率为每1000个细胞（1.1±0.4）。
