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[抗坏血酸对8-甲氧基补骨脂素光致突变作用及钼酸铵诱导人淋巴细胞损伤的抗断裂效应]

[The anticlastogenic effect of ascorbic acid in relation to the damages induced in human lymphocytes by the photomutagenic action of 8-methoxypsoralen and by ammonium molybdate].

作者信息

Makedonov G P, Bobyleva L A, Chekova V V, Zasukhina G D

出版信息

Radiats Biol Radioecol. 1995 Sep-Oct;35(5):726-9.

PMID:7489108
Abstract

In experiments with cultured human lymphocytes anticlastogenic effect of ascorbic acid (AA) with respect to photomutagenic action of 8-methoxypsoralen (8-MOP) and ammonium molibdenate (Mo) was studied. It was found that AA effectively protected from mutagenic action of Mo. Effective protection of cells from 8-MOP monoadducts and DNA interstrand links was also observed.

摘要

在对培养的人淋巴细胞进行的实验中，研究了抗坏血酸（AA）对8-甲氧基补骨脂素（8-MOP）和钼酸铵（Mo）光致突变作用的抗致突变效应。发现AA能有效保护细胞免受Mo的诱变作用。还观察到AA对细胞免受8-MOP单加合物和DNA链间交联的有效保护作用。

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