Hewitt G, Halliday I, McCaigue M, Campbell G, Rowlands B, Diamond T
Department of Surgery, Queen's University of Belfast, UK.
Br J Surg. 1995 Oct;82(10):1424-6. doi: 10.1002/bjs.1800821043.
This study compared mortality rates, endotoxaemia, systemic tumour necrosis factor (TNF) and interleukin (IL)-6 concentrations after continuous and intermittent hepatic ischaemia. Two groups of rats were subjected to continuous or intermittent left hepatic inflow occlusion for a total period of 120 min in each group. Intermittent ischaemia was associated with significantly lower mortality rates than continuous ischaemia (four of 20 versus 15 of 20; P = 0.0015). In a separate study, again following 120 min continuous or intermittent ischaemia, systemic blood was sampled at 0 min, 1 h, 3 h and 5 h after final clamp release for measurement of endotoxin, TNF and IL-6 concentrations. Endotoxin concentrations were significantly lower at 1 h, as were TNF and IL-6 concentrations at 3 and 5 h, after final clamp release in the group having intermittent ischaemia (P < 0.05). Intermittent ischaemia is associated therefore with significantly reduced mortality rates and lower systemic endotoxin, TNF and IL-6 concentrations when compared with continuous ischaemia.
本研究比较了持续性和间歇性肝脏缺血后的死亡率、内毒素血症、全身肿瘤坏死因子（TNF）和白细胞介素（IL）-6浓度。两组大鼠分别接受持续性或间歇性左肝血流阻断，每组总时长为120分钟。与持续性缺血相比，间歇性缺血的死亡率显著更低（20只中有4只死亡，而持续性缺血组20只中有15只死亡；P = 0.0015）。在另一项研究中，同样在持续性或间歇性缺血120分钟后，于最后一次松开血管夹后的0分钟、1小时、3小时和5小时采集全身血液样本，以测量内毒素、TNF和IL-6浓度。在间歇性缺血组中，最后一次松开血管夹后1小时的内毒素浓度显著更低，3小时和5小时的TNF和IL-6浓度也显著更低（P < 0.05）。因此，与持续性缺血相比，间歇性缺血与死亡率显著降低以及全身内毒素、TNF和IL-6浓度降低相关。
