Badger I L, Townsend P, Buckels J A
Liver Research Laboratories, Queen Elizabeth Hospital, Birmingham.
Gut. 1992 May;33(5):694-7. doi: 10.1136/gut.33.5.694.
A leporine model to investigate tumour necrosis factor alpha (TNF alpha) secretion after peripheral vein or mesenteric vein lipopolysaccharide injection was devised. Mesenteric vein injection provoked lower arterial concentrations after 90 minutes (median (range), 2.81, (0.75-11.96) ng/ml) than peripheral vein injection (7.00 (4.27-14.95) ng/ml (p less than 0.05)). Mesenteric vein injection after 10 minutes' warm hepatic ischaemia, which impairs hepatic clearance, provoked higher median arterial TNF alpha values at 90 minutes (7.98 (2.85-21.48) ng/ml) than in normal animals (p less than 0.05). Portal vein endotoxaemia induced less TNF alpha production than systemic endotoxaemia unless hepatic clearance was impaired, thus the major source of TNF alpha in systemic endotoxaemia is probably extrahepatic.
设计了一种兔模型，用于研究外周静脉或肠系膜静脉注射脂多糖后肿瘤坏死因子α（TNFα）的分泌情况。肠系膜静脉注射后90分钟的动脉浓度（中位数（范围），2.81，（0.75 - 11.96）ng/ml）低于外周静脉注射（7.00（4.27 - 14.95）ng/ml（p < 0.05））。10分钟的温热性肝缺血后进行肠系膜静脉注射，这会损害肝脏清除功能，90分钟时动脉TNFα的中位数高于正常动物（7.98（2.85 - 21.48）ng/ml（p < 0.05））。除非肝脏清除功能受损，门静脉内毒素血症诱导产生的TNFα比全身内毒素血症少，因此全身内毒素血症中TNFα的主要来源可能是肝外的。
