Haffner S M, González C, Miettinen H, Howard B V, Stern M P
Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio 78284-7873, USA.
Arterioscler Thromb Vasc Biol. 1995 Dec;15(12):2136-41. doi: 10.1161/01.atv.15.12.2136.
Recent studies suggest that a relative abundance of small dense LDL is a risk factor for coronary heart disease. We compared LDL size in Mexico City residents (n = 191) and San Antonio Mexican Americans (n = 282), two genetically similar populations that differ markedly in dietary behaviors: in Mexico City approximately 62% of calories are from carbohydrate and approximately 19% from fat, and in San Antonio approximately 40% of calories are from carbohydrate and approximately 40% from fat. Mean LDL size in Mexico City was 258.6 +/- 0.9 A, and in San Antonio, 255.9 +/- 0.6 A (P = .013). After adjustment for the higher triglyceride and lower HDL cholesterol levels (the two most important predictors of LDL size) in Mexico City, LDL size was significantly lower in San Antonio than in Mexico City by -8.33 +/- 0.84 A (P < .001). Our data suggest that the higher triglyceride concentrations in Mexico City residents that are associated with a higher carbohydrate diet may not be associated with atherogenic changes in LDL.
近期研究表明，小而密低密度脂蛋白（LDL）的相对丰度是冠心病的一个危险因素。我们比较了墨西哥城居民（n = 191）和圣安东尼奥墨西哥裔美国人（n = 282）的LDL大小，这两个基因相似的人群在饮食行为上有显著差异：在墨西哥城，约62%的热量来自碳水化合物，约19%来自脂肪；在圣安东尼奥，约40%的热量来自碳水化合物，约40%来自脂肪。墨西哥城的平均LDL大小为258.6 +/- 0.9 Å，圣安东尼奥为255.9 +/- 0.6 Å（P = 0.013）。在对墨西哥城较高的甘油三酯水平和较低的高密度脂蛋白胆固醇水平（LDL大小的两个最重要预测因素）进行校正后，圣安东尼奥的LDL大小比墨西哥城显著低-8.33 +/- 0.84 Å（P < 0.001）。我们的数据表明，墨西哥城居民中与高碳水化合物饮食相关的较高甘油三酯浓度可能与LDL的致动脉粥样硬化变化无关。
