印度尼西亚东爪哇省学龄儿童乙型肝炎病毒的血清学和分子特征。
Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia.
机构信息
Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia.
出版信息
Am J Trop Med Hyg. 2010 Jul;83(1):189-93. doi: 10.4269/ajtmh.2010.09-0589.
Abstract
Universal childhood hepatitis B vaccination was introduced in Indonesia in 1997; by 2008, coverage was estimated to be 78%. This study aimed to investigate the serologic status and virologic characteristics of hepatitis B virus (HBV) among the children in East Java. A total of 229 healthy children born during 1994-1999 were enrolled in this study. Overall, 3.1% were positive for hepatitis B surface antigen (HBsAg) and 23.6% were positive for antibody to HBsAg (anti-HBs). HBV DNA was detected in 5 of 222 HBsAg-negative carriers, which were suggested to be cases of occult HBV infection. A single amino substitution (T126I) in the S region was frequently found. HBV infection remains endemic, and the prevalence of anti-HBs remains insufficient among children in East Java, Indonesia.
摘要
1997 年印度尼西亚开始在全国范围内为儿童普遍接种乙肝疫苗；到 2008 年，覆盖率估计达到 78%。本研究旨在调查东爪哇儿童中乙型肝炎病毒（HBV）的血清学状况和病毒学特征。本研究共纳入了 229 名 1994-1999 年期间出生的健康儿童。总体而言，3.1%的儿童 HBsAg 阳性，23.6%的儿童抗-HBs 阳性。在 222 名 HBsAg 阴性携带者中，有 5 名检测到 HBV DNA，提示存在隐匿性 HBV 感染。在 S 区经常发现单个氨基酸取代（T126I）。HBV 感染仍然流行，印度尼西亚东爪哇的儿童中抗-HBs 的流行率仍然不足。
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