加巴喷丁在儿童中的毒性表现为行为改变。

Gabapentin toxicity in children manifesting as behavioral changes.

作者信息

Wolf S M, Shinnar S, Kang H, Gil K B, Moshé S L

机构信息

Department of Neurology, Montefiore/Einstein Epilepsy Management Center, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.

出版信息

Epilepsia. 1995 Dec;36(12):1203-5. doi: 10.1111/j.1528-1157.1995.tb01063.x.

DOI:10.1111/j.1528-1157.1995.tb01063.x

PMID:7489697

Abstract

Pediatric experience with gabapentin (GBP), a new antiepileptic drug (AED), is limited. We described 3 learning disabled children, 1 aged 7 and 2 aged 10 years, with intractable partial seizures who developed severe behavioral problems while receiving modest doses of GBP. The children became hyperactive and had explosive outburst consisting of aggressive and oppositional behavior. The behavioral problems were sufficiently severe to require discontinuation of GBP despite moderately improved seizure control.

摘要

新型抗癫痫药物（AED）加巴喷丁（GBP）在儿科的应用经验有限。我们描述了3名学习障碍儿童，1名7岁，2名10岁，患有顽固性部分性癫痫，在接受中等剂量GBP治疗时出现了严重的行为问题。这些儿童变得多动，出现了包括攻击和对立行为在内的爆发性发作。尽管癫痫控制有一定改善，但行为问题严重到足以需要停用GBP。