Chin H, Kwon O J, Jung H H, Kim D S, Kozak C A
Laboratory of Neurochemistry, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA.
Genomics. 1995 Aug 10;28(3):592-5. doi: 10.1006/geno.1995.1196.
The genes encoding the alpha 1 and beta subunits of voltage-sensitive calcium channel were mapped in the mouse by analysis of the progeny of two multilocus crosses. The alpha 1, beta 2, and beta 4 subunit genes, termed Cchna1, Cchb2, and Cchb4, are located at different sites on proximal Chr 2, while the beta 3 subunit gene Cchb3 maps to Chr 15 near Wnt1. These results together with previous mapping data indicate that the calcium channel genes are dispersed in the mouse genome, unlike the sodium channel genes, which are clustered.
通过对两个多位点杂交后代的分析，在小鼠中定位了编码电压敏感性钙通道α1和β亚基的基因。α1、β2和β4亚基基因，分别称为Cchna1、Cchb2和Cchb4，位于近端2号染色体的不同位点，而β3亚基基因Cchb3定位于15号染色体上靠近Wnt1的位置。这些结果与之前的定位数据表明，与成簇的钠通道基因不同，钙通道基因在小鼠基因组中是分散分布的。
