盘霉素的构效关系：烷基取代基的影响

Structure-activity relationship of pamamycins: effects of alkyl substituents.

作者信息

Natsume M, Tazawa J, Yagi K, Abe H, Kondo S, Marumo S

机构信息

Department of Applied Biological Sciences, Tokyo University of Agriculture and Technology, Japan.

出版信息

J Antibiot (Tokyo). 1995 Oct;48(10):1159-64. doi: 10.7164/antibiotics.48.1159.

DOI:10.7164/antibiotics.48.1159

PMID:7490225

Abstract

Nine new pamamycin homologues were isolated from the culture broth of Streptomyces alboniger IFO 12738 using a combination of ODS and NH2 HPLCs, and their structures determined by GC-MS. The structural differences in these homologues are in the numbers and positions of methyl and ethyl groups. The aerial mycelium-inducing and growth-inhibitory activities in S. alboniger of these homologues and their antibiotic activity against Bacillus subtilis were examined. The effects of the alkyl substituents on these activities are discussed.

摘要

利用ODS和NH2高效液相色谱联用技术，从白色链霉菌IFO 12738的培养液中分离出9种新的帕马霉素同系物，并通过气相色谱-质谱联用仪确定了它们的结构。这些同系物的结构差异在于甲基和乙基的数量及位置。考察了这些同系物对白色链霉菌气生菌丝的诱导作用和生长抑制活性，以及它们对枯草芽孢杆菌的抗菌活性。讨论了烷基取代基对这些活性的影响。