螺旋菌素，一种来自紫色链霉菌Tü 4113的新型抗真菌抗生素。
Spirofungin, a new antifungal antibiotic from Streptomyces violaceusniger Tü 4113.
作者信息
Höltzel A, Kempter C, Metzger J W, Jung G, Groth I, Fritz T, Fiedler H P
机构信息
Institut für Organische Chemie, Universität Tübingen, Germany.
出版信息
J Antibiot (Tokyo). 1998 Aug;51(8):699-707. doi: 10.7164/antibiotics.51.699.
PMID:9766461
Abstract
A new secondary metabolite was detected in the culture filtrate and extracts of Streptomyces violaceusniger Tü 4113 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compound named spirofungin has a polyketide-spiroketal structure and shows various antifungal activities, particularly against yeasts.
摘要
通过高效液相色谱-二极管阵列检测和高效液相色谱-电喷雾-质谱筛查，在紫色链霉菌Tü 4113的培养滤液和提取物中检测到一种新的次生代谢产物。这种名为螺旋菌素的化合物具有聚酮-螺环缩酮结构，并表现出多种抗真菌活性，尤其是对酵母的活性。
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