Atrah H I, Parry J V, Gough D, Tosswill J, Ala F A
West Midlands Regional Blood Transfusion Service, Edgbaston, Birmingham.
J Clin Pathol. 1995 Sep;48(9):865-7. doi: 10.1136/jcp.48.9.865.
Since 1985, over 1,800,000 donations have been screened by the West Midlands Regional Blood Transfusion Service for antibody to HIV. Twelve regular donors gave three or more donations that were alternatingly positive and negative in the screening test, but not confirmed to be HIV positive by supplementary testing. Extensive investigation of six of these donors, including the polymerase chain reaction (PCR), failed to confirm HIV infection. The donors were reassured but, nevertheless, retired to comply with the guidelines of the National Blood Transfusion Service. These findings indicate that, for UK donors, ambiguous serological findings are unlikely to reflect HIV infection. On the rare occasions where serological results are particularly ambiguous, PCR testing of donors' blood may be helpful.
自1985年以来，西米德兰兹地区输血服务中心已对超过180万份捐赠血液进行了HIV抗体筛查。12名定期献血者的三次或更多次献血在筛查测试中呈交替阳性和阴性，但补充检测未确认其HIV呈阳性。对其中6名献血者进行了包括聚合酶链反应（PCR）在内的广泛调查，未能确认其感染HIV。献血者得到了安抚，但仍按国家输血服务中心的指导方针停止献血。这些结果表明，对于英国献血者而言，血清学结果不明确不太可能反映HIV感染。在血清学结果极为不明确的罕见情况下，对献血者血液进行PCR检测可能会有所帮助。
