[Virus-like particles in the sera of patients with viral hepatitis and donors with antigenemia].

Isopicnic centrifugation in cesium chloride gradient produces sufficiently homogeneous fractions of large (42--45 nm) and small (20--22 nm) particles detectable in sera from patients with viral hepatitis and donors with antigenemia. In addition to morphological criteria, differences between these particles were indicated by a greater buoyant density (1.24 g/cm3), higher sensitivity to lower pH values and a lower resistance between. No antigenic determinats inherent in small particles could be found in large particles.