Cunningham S, Fleck B W, Elton R A, McIntosh N
Department of Child Life and Health, University of Edinburgh, UK.
Lancet. 1995 Dec 2;346(8988):1464-5. doi: 10.1016/s0140-6736(95)92475-2.
Retinopathy of prematurity (ROP) is a potentially blinding disease of preterm infants. 21 days of computer-recorded transcutaneous oxygen (TcPO2) data were compared in 31 infants with stage 3 or greater ROP and 38 infants with no ROP or stage 1 or 2. In a multiple logistic regression adjusted for significant perinatal factors (birthweight, gestation, and intraventricular haemorrhage), babies with stage 3 or higher ROP showed an increased variability of TcPO2 in week 1 (p < 0.01) and 2 (p = 0.012) but not week 3. Variability of TcPO2 in the first 2 weeks of life is a significant predictor of severe ROP.
早产儿视网膜病变（ROP）是一种可能导致早产儿失明的疾病。对31例患有3期或更严重ROP的婴儿和38例无ROP或患有1期或2期ROP的婴儿的21天计算机记录的经皮氧分压（TcPO2）数据进行了比较。在对重要围产期因素（出生体重、孕周和脑室内出血）进行调整的多元逻辑回归分析中，患有3期或更高期ROP的婴儿在第1周（p < 0.01）和第2周（p = 0.012）的TcPO2变异性增加，但在第3周没有增加。出生后前2周的TcPO2变异性是严重ROP的重要预测指标。
