Coons T
American Society of Radiologic Technologists, Publications Department, Albuquerque, NM 87123-3917, USA.
Radiol Technol. 1995 Sep-Oct;67(1):39-60; quiz 61-4.
Monoclonal antibodies, or "MoAbs," have revolutionized clinical approaches to diagnostic imaging and therapy of many diseases. The use of MoAbs for diagnosing and treating cancer has been especially promising. However, the full potential of these "magic bullets" has yet to be realized. This article examines the current and potential uses of MoAbs, describes problems with the technology and looks at potential solutions. Along with descriptions of how MoAbs are made and prepared for use in the clinic, the article provides examples of the ways in which MoAbs can be used to complement and expand the information obtained from standard diagnostic imaging modalities. Specific examples of the use of monoclonal antibodies for treating cancer and other diseases also are provided.
单克隆抗体，即“MoAbs”，已经彻底改变了许多疾病诊断成像和治疗的临床方法。单克隆抗体在癌症诊断和治疗方面的应用尤其具有前景。然而，这些“神奇子弹”的全部潜力尚未实现。本文探讨了单克隆抗体的当前及潜在用途，描述了该技术存在的问题，并探讨了潜在的解决方案。除了介绍单克隆抗体的制备方法以及如何准备用于临床之外，本文还提供了一些示例，说明单克隆抗体如何用于补充和扩展从标准诊断成像模式中获得的信息。还提供了单克隆抗体用于治疗癌症和其他疾病的具体实例。
