Tobocman W, Santosh K, Carter J R, Haacke E M
Department of Physics, Case Western Reserve University, Cleveland, OH 44106, USA.
Ultrasonics. 1995 Jul;33(4):331-40. doi: 10.1016/0041-624x(95)00025-x.
Reflections of 4 MHz ultrasound pulses from 60 sites on 15 human aorta specimens were analysed using the plane-wave Born approximation (PWBA) inverse scattering method. The recovered high-resolution acoustic impedance profile for each site was correlated with an analysis (by microscope) of sections taken from that site. The shape of the impedance profile was found to be sensitive to the pathology of the tissue at each site. The severity of the various conditions could be gauged from the recovered impedance profiles. Some of the insonifications were done on aorta specimens that were shielded from the ultrasound transducer by a human tissue specimen about 1.25 cm thick in order to study the effects of intervening tissue. We found that it was possible to compensate for the distortion due to the frequency dependent attenuation of the intervening tissue. We conclude that ultrasound imaging, with the reflections analysed by means of PWBA inverse scattering provides a promising non-invasive tissue characterization modality.
使用平面波玻恩近似（PWBA）逆散射方法分析了来自15个人类主动脉标本上60个部位的4兆赫超声脉冲的反射。为每个部位恢复的高分辨率声阻抗剖面与从该部位获取的切片的显微镜分析结果相关联。发现阻抗剖面的形状对每个部位组织的病理学敏感。可以从恢复的阻抗剖面中判断各种病症的严重程度。为了研究中间组织的影响，一些声照射是在由约1.25厘米厚的人体组织标本屏蔽超声换能器的主动脉标本上进行的。我们发现可以补偿由于中间组织的频率依赖性衰减引起的失真。我们得出结论，通过PWBA逆散射分析反射的超声成像提供了一种有前途的非侵入性组织表征方式。
