Jacques P F, Halpner A D, Blumberg J B
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Am J Clin Nutr. 1995 Dec;62(6):1228-33. doi: 10.1093/ajcn/62.6.1228.
Data from a cross-sectional survey of 746 non-institutionalized, Boston-area elderly individuals (aged > or = 60 y) were analyzed to assess the relation between antioxidant nutrient intake and plasma antioxidant status. Intakes of vitamin C and carotenoids and supplemental vitamin E were estimated by using 3-d diet records. Mean plasma concentrations of these nutrients were calculated within categories of intake, and polynomial contrasts were used to test for linear trends of the plasma nutrient concentrations across these categories. Adjustments for the corresponding intake of the plasma nutrient under consideration, as well as age, sex, and smoking status were made to minimize potential confounding. Plasma alpha-tocopherol concentrations were 18% greater in individuals consuming > or = 220 mg vitamin C/d compared with those with intakes < 120 mg/d (P for trend < 0.001). Plasma carotenoid concentrations were 13% higher across increasing categories of vitamin C intake (P for trend = 0.002). An increasing intake of carotenoids was moderately associated with higher plasma alpha-tocopherol (P for trend = 0.008) and unrelated to ascorbic acid status. An increasing intake of supplemental vitamin E was weakly correlated with plasma ascorbic acid (P for trend = 0.05) and unrelated to carotenoid status. These results provide epidemiologic evidence that increasing intake of either vitamin C, vitamin E, or carotenoids is associated with greater plasma concentrations of one or both of the other antioxidant vitamins and not associated with any impairment in antioxidant status.
对746名居住在波士顿地区、未被收容机构收留的老年人（年龄≥60岁）进行横断面调查所获数据进行分析，以评估抗氧化营养素摄入量与血浆抗氧化状态之间的关系。通过3天饮食记录来估算维生素C、类胡萝卜素的摄入量以及维生素E补充剂的摄入量。在不同摄入量类别中计算这些营养素的平均血浆浓度，并使用多项式对比来检验血浆营养素浓度在这些类别中的线性趋势。对所考虑的血浆营养素的相应摄入量以及年龄、性别和吸烟状况进行调整，以尽量减少潜在的混杂因素。与维生素C摄入量<120mg/d的个体相比，维生素C摄入量≥220mg/d的个体血浆α-生育酚浓度高18%（趋势P<0.001）。随着维生素C摄入量增加，血浆类胡萝卜素浓度升高13%（趋势P=0.002）。类胡萝卜素摄入量增加与较高的血浆α-生育酚适度相关（趋势P=0.008），与抗坏血酸状态无关。补充维生素E摄入量增加与血浆抗坏血酸弱相关（趋势P=0.05），与类胡萝卜素状态无关。这些结果提供了流行病学证据，即增加维生素C、维生素E或类胡萝卜素的摄入量与其他一种或两种抗氧化维生素的血浆浓度升高相关，且与抗氧化状态的任何损害无关。
