Sturgis E M, Miller R H
Department of Otolaryngology-Head and Neck Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Ann Otol Rhinol Laryngol. 1995 Dec;104(12):946-54. doi: 10.1177/000348949510401206.
With improvements in locoregional control, the problem of second primary malignancies is rapidly being pushed to the forefront of head and neck oncology. While the constant long-term risk for the head and neck cancer patient has been well established, efforts at prevention, early detection, and treatment have been somewhat futile. Recent advances in genetic predisposition, biomarkers, photodiagnostic imaging, and differentiation therapy may soon offer improved outcomes. The literature is reviewed and current research is presented regarding the history, epidemiology, etiology, diagnosis, and treatment of second primary malignancies.
随着局部区域控制的改善，第二原发性恶性肿瘤问题正迅速成为头颈肿瘤学的前沿问题。虽然头颈癌患者持续存在的长期风险已得到充分证实，但预防、早期检测和治疗方面的努力收效甚微。遗传易感性、生物标志物、光诊断成像和分化疗法的最新进展可能很快会带来更好的治疗效果。本文回顾了相关文献，并介绍了有关第二原发性恶性肿瘤的历史、流行病学、病因、诊断和治疗的当前研究。
