Tomita T, McLone D G
Neurosurgery. 1985 Dec;17(6):913-9. doi: 10.1227/00006123-198512000-00008.
One hundred patients with brain tumors were diagnosed and treated during the first 24 months of life. They represent 16% of 608 children with brain tumors treated from 1952 through 1984. The most common histological type of brain tumors during the first 24 months are benign astrocytoma, medulloblastoma, and choroid plexus papilloma. The tumor location is distributed relatively evenly among the cerebellum and the 4th ventricle, the cerebral hemisphere (including the lateral ventricle), and the suprasellar region and 3rd ventricle. The chief presenting signs and symptoms are a full fontanelle, macrocephaly, changes of behavior, and delayed developmental milestones. Localizing signs are infrequent. Ninety-two patients underwent craniotomy with a one-month surgical mortality rate of 12%. The surgical mortality rate was 5.6% among 36 recent patients diagnosed by computed tomography. The 5-year survival rate is 41% in the patients younger than 12 months and 74% in patients diagnosed during the 2nd year of life. This study indicates the validity of Collins' rule for medulloblastomas during the first 24 months of life, but not for benign or malignant astrocytomas.
100例脑肿瘤患者在出生后的前24个月内被诊断并接受治疗。他们占1952年至1984年期间接受治疗的608例儿童脑肿瘤患者的16%。出生后头24个月内最常见的脑肿瘤组织学类型为良性星形细胞瘤、髓母细胞瘤和脉络丛乳头状瘤。肿瘤位置在小脑和第四脑室、大脑半球（包括侧脑室）、鞍上区和第三脑室之间分布相对均匀。主要的临床表现和症状为囟门饱满、巨头畸形、行为改变和发育里程碑延迟。定位体征不常见。92例患者接受了开颅手术，1个月手术死亡率为12%。在最近36例经计算机断层扫描诊断的患者中，手术死亡率为5.6%。12个月以下患者的5年生存率为41%，出生后第二年诊断的患者为74%。本研究表明柯林斯规则对出生后头24个月内的髓母细胞瘤有效，但对良性或恶性星形细胞瘤无效。
