Sieratzki J S, Gompels C, Poyser K, Beaman J, Savage D C
Bristol Royal Hospital for Sick Children.
Arch Dis Child. 1995 Oct;73(4):351-3. doi: 10.1136/adc.73.4.351.
The use of filter paper four point 24 hour cortisol profiles in the diagnosis and management of secondary adrenocortical deficiency was examined. Eighteen children with familial short stature and isolated growth hormone deficiency had normal 24 hour and morning plasma cortisol concentrations measured. Eight of 11 children with multiple pituitary hormone deficiencies had evidence of hypocorticalism despite previously normal baseline cortisols or responses to insulin hypoglycaemia or tetracosactrin. Nine of 11 children with hypopituitarism on replacement treatment (4.9-12.5 mg/m2/day) had satisfactory concentrations of cortisol, though morning cortisols were often low. Filter paper profiles are a simple, inexpensive, and relatively non-invasive way of managing children with suspected hypocorticalism and of monitoring their treatment.
研究了使用滤纸四点24小时皮质醇谱在继发性肾上腺皮质功能减退的诊断和管理中的应用。对18名家族性身材矮小和孤立性生长激素缺乏的儿童进行了24小时及早晨血浆皮质醇浓度测定，结果均正常。11名患有多种垂体激素缺乏的儿童中，有8名尽管之前基线皮质醇正常或对胰岛素低血糖或二十四肽促皮质素反应正常，但仍有肾上腺皮质功能减退的证据。11名接受替代治疗（4.9 - 12.5 mg/m²/天）的垂体功能减退儿童中，有9名皮质醇浓度令人满意，不过早晨皮质醇水平常常较低。滤纸谱是一种简单、廉价且相对非侵入性的方法，可用于管理疑似肾上腺皮质功能减退的儿童并监测其治疗情况。
