Veale D J, Collidge T A, Belch J J
University Department of Medicine, Ninewells Hospital, Dundee, United Kingdom.
Ann Rheum Dis. 1995 Oct;54(10):853-5. doi: 10.1136/ard.54.10.853.
To determine the prevalence of symptomatic macrovascular disease, as defined by the World Health Organisation questionnaire for intermittent claudication, in patients with systemic sclerosis (SSc), and to compare the prevalence in this population with a cross sectional population study group reported in the Edinburgh Artery Study (EAS).
A group of 53 patients with a diagnosis of limited or diffuse systemic sclerosis were identified from our register. They were asked to complete the WHO questionnaire to establish the presence or absence of intermittent claudication. In addition, each patient's case notes were reviewed to establish the existence of definite peripheral vascular disease and to determine their risk factor profile.
Forty six patients responded to the questionnaire, giving a response rate of 87%. Intermittent claudication was found in 10 SSc patients (21.7%) according to the questionnaire (two with diffuse and eight with limited SSc), compared with a prevalence rate of 4.6% for claudication in the EAS. Three SSc patients experienced clinical events attributable to occlusion of a major artery proven on angiography. Four patients had hypertension, there were three current and four ex-smokers, and two had increased total cholesterol. None of these patients had diabetes.
This study demonstrated a greater prevalence of macrovascular disease in patients with SSc than had been found in a neighbouring population.
根据世界卫生组织关于间歇性跛行的调查问卷，确定系统性硬化症（SSc）患者中有症状的大血管疾病的患病率，并将该人群的患病率与爱丁堡动脉研究（EAS）中报告的横断面人群研究组进行比较。
从我们的登记册中确定了一组53例诊断为局限性或弥漫性系统性硬化症的患者。要求他们完成世界卫生组织的调查问卷，以确定是否存在间歇性跛行。此外，查阅了每位患者的病历，以确定是否存在明确的外周血管疾病，并确定其危险因素概况。
46例患者对问卷做出了回应，回应率为87%。根据问卷，10例SSc患者（21.7%）存在间歇性跛行（2例为弥漫性SSc，8例为局限性SSc），而EAS中跛行的患病率为4.6%。3例SSc患者经历了血管造影证实的主要动脉闭塞所致的临床事件。4例患者患有高血压，3例为现吸烟者，4例为既往吸烟者，2例总胆固醇升高。这些患者均无糖尿病。
本研究表明，SSc患者中大血管疾病的患病率高于邻近人群。
