Cascone M G, Sim B, Downes S
Department of Chemical Engineering, University of Pisa, Italy.
Biomaterials. 1995 May;16(7):569-74. doi: 10.1016/0142-9612(95)91131-h.
In order to overcome the biological deficiencies of synthetic polymers and to enhance the mechanical characteristics of natural polymers, two synthetic polymers, poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) were blended, in different ratios, with two biological polymers, collagen (C) and hyaluronic acid (HA). These blends were used to prepare films, sponges and hydrogels which were loaded with growth hormone (GH) to investigate their potential use as drug delivery systems. The GH release was monitored in vitro using a specific enzyme-linked immunosorbent assay. The results show that GH can be released from HA/PAA sponges and from HA/PVA and C/PVA hydrogels. The initial GH concentration used for sample loading affected the total quantity of GH released but not the pattern of release. The rate and quantity of GH released was significantly dependent on the HA or C content of the polymers.
为了克服合成聚合物的生物学缺陷并增强天然聚合物的机械特性，将两种合成聚合物，即聚乙烯醇（PVA）和聚丙烯酸（PAA），以不同比例与两种生物聚合物，即胶原蛋白（C）和透明质酸（HA）进行混合。这些混合物被用于制备负载生长激素（GH）的薄膜、海绵和水凝胶，以研究它们作为药物递送系统的潜在用途。使用特定的酶联免疫吸附测定法在体外监测GH的释放。结果表明，GH可以从HA/PAA海绵以及HA/PVA和C/PVA水凝胶中释放出来。用于样品加载的初始GH浓度影响释放的GH总量，但不影响释放模式。GH的释放速率和量显著取决于聚合物中HA或C的含量。
